Apnea of Prematurity: Caffeine Dose Optimization

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Effect of Caffeine and Aminophylline on Apnea of Prematurity

Background: The most common type of apnea among premature newborns is idiopathic apnea of prematurity. Recurrent apnea can lead to hypoxemia and central nervous system damage. Although caffeine and theophylline are the most commonly prescribed drugs in this field, there is disagreement about which medicine is preferred. The purpose of this study was to compare the ther...

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Caffeine therapy for apnea of prematurity.

BACKGROUND Methylxanthines reduce the frequency of apnea of prematurity and the need for mechanical ventilation during the first seven days of therapy. It is uncertain whether methylxanthines have other short- and long-term benefits or risks in infants with very low birth weight. METHODS We randomly assigned 2006 infants with birth weights of 500 to 1250 g during the first 10 days of life to ...

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Comparison between Caffeine and Theophylline Therapy for Apnea of Prematurity

Purpose: Methylxanthines are commonly used to treat apnea of prematurity. Recent studies have reported that caffeine therapy reduces the rate of bronchopulmonary dysplasia (BPD) and improves the rate of survival in preterm infant without neuro­ developmental disabilities. This study was performed to compare the effects on apnea episodes, adverse effects and morbidity between the caffeine and th...

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Long-term effects of caffeine therapy for apnea of prematurity.

BACKGROUND Methylxanthine therapy is commonly used for apnea of prematurity but in the absence of adequate data on its efficacy and safety. It is uncertain whether methylxanthines have long-term effects on neurodevelopment and growth. METHODS We randomly assigned 2006 infants with birth weights of 500 to 1250 g to receive either caffeine or placebo until therapy for apnea of prematurity was n...

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Apnea of prematurity

Apnea of prematurity (AOP) is one of the most frequent pathologies in the Neonatal Intensive Care Unit, with an incidence inversely related to gestational age. Its etiology is often multi factorial and diagnosis of idiopathic forms requires exclusion of other underlying diseases. Despite being a selflimiting condition which regresses with the maturation of the newborn, possible long-term effect...

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ژورنال

عنوان ژورنال: The Journal of Pediatric Pharmacology and Therapeutics

سال: 2013

ISSN: 1551-6776

DOI: 10.5863/1551-6776-18.1.45